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Long Covid Symptoms May Be Caused by Micro Clots, Scientists Say

Some of the symptoms of so-called long-covid may be caused by inflammatory molecules trapped inside tiny blood clots.

Long Covid Symptoms May Be Caused by Micro Clots, Scientists Say
A healthcare worker treats a patient inside a negative pressure room in the Covid-19 intensive care unit. (Photographer: Angus Mordant/Bloomberg)

Some of the symptoms of so-called long-covid, the ailments that can persist for months after a Covid-19 infection, may be caused by inflammatory molecules trapped inside tiny blood clots, a scientist at South Africa’s Stellenbosch University said. 

High levels of inflammatory molecules were found in micro clots in blood samples from people with long-covid, Resia Pretorius, a researcher at the university, said in a statement on Monday. The molecules contained fibrinogen, a clotting protein, and alpha(2)-antiplasmin, which prevents the breakdown of blood clots, she said.

These “might be the cause of some of the lingering symptoms experienced by individuals with long-covid,” the university said in the statement. This “provides further evidence that Covid-19, and now long-covid, have significant cardiovascular and clotting pathologies.”

The research, which has been peer reviewed and published in the Cardiovascular Diabetology journal, was based on samples from 100 long-covid sufferers. A larger study is planned.

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