Asian Patients (Finally) Have Medicines Designed for Them

(Bloomberg) -- For decades, much of the pipeline of medical innovation has flowed from West to East. Now a string of companies are attempting to upend that trend with new drugs and products tailored to Asian bodies and lifestyles.

There’s the Singapore-based drugmaker tackling an obscure cancer that’s rare in the West but common in Asia, where it’s been linked to a popular fish dish. Med-tech startups are preparing to sell tests to detect tumors more accurately in Asian women with denser breast tissue, including one wearable device that slips into a bra. Even Big Pharma firms like AstraZeneca Plc and Roche Holding AG now have drugs targeting a lung cancer-causing mutation most often found in women from East Asia.

This simple yet radical departure comes as Asia’s booming economies and rising incomes enable higher spending on health care. That’s providing incentive for more pharmaceutical companies to set up shop in the region, whether it’s Western firms creating R&D centers to develop drugs for local populations, or new Asian drugmakers springing up. Consultancy Frost & Sullivan predicts that total revenue for the Asian health-care industry will jump 11 percent this year to $517 billion.

Many of the researchers focusing on Asia have a simple starting point: Diseases and their cures can sometimes work differently in different populations, and a one-size-fits-all regimen tailored to the West isn’t sufficient. The approach is cropping up most often in cancer care in Asia, home to tumors that are rare in the West.

"The patients are here, the tumor samples are here, and also the basic know-how," said Brigette Ma, a professor at the Chinese University of Hong Kong who specializes in new drug development. "By acknowledging diversity, not just in cultural and economic needs -- by acknowledging diversity in terms of cancer care -- we are getting the drugs to where they are needed."

Bile Duct

The shift is part of a broader trend sweeping through the global health-care industry called precision medicine, which seeks to tailor treatment to a person’s specific genetic makeup and circumstances, including the ones commonly shared among people of the same ethnic group or culture.

In Asia, Japan has long been an important market for the health-care industry, and a site of new discoveries. But the rapid growth of the rest of the region is heightening its importance as a whole, and diversifying the industry’s focus in it.

Singapore-based biotech company Aslan Pharmaceuticals Ltd. is now conducting late-stage human tests for a drug targeting bile duct and gastric cancers.

The prevalence throughout Asia of a stomach-infecting bacteria which can lead to cancer-causing inflammation is one factor that makes gastric cancer more common in the region. But research suggests it usually takes even more culturally specific traits, like the aggravating diet of salty and fermented foods common in Northern China, Korea and Japan, to turn that inflammation cancerous.

Northeastern Thailand, meanwhile, is the global center for an obscure disease called bile duct cancer. Rare in the West, researchers have traced its prevalence in certain parts of Southeast Asia to a fermented fish dish called koi pla beloved by the area’s Lao people. The cooking process for the dish often fails to kill an inflammation-causing parasite called the liver fluke, and the infection can eventually lead to bile-duct cancer.

"There are very few effective treatment options for these patients," said Carl Firth, Aslan’s chief executive officer. "The focus was very much on cancers that were common in the West."

Aslan has received orphan drug status for its lead molecule in the U.S. as a potential treatment for biliary tract and gastric cancers, and is seeking approval to sell it both there and in China. When it comes to patients in less affluent parts of Asia, like bile duct cancer patients in Thailand, Firth said his company could look for ways to help them access the drug after completing its clinical trials.